Erythropoietin-independent erythrocyte production: signals through gp130 and c-kit dramatically promote erythropoiesis from human CD34+ cells

@article{Sui1996ErythropoietinindependentEP,
  title={Erythropoietin-independent erythrocyte production: signals through gp130 and c-kit dramatically promote erythropoiesis from human CD34+ cells},
  author={Xingwei Sui and Kohichiro Tsuji and Sakura Tajima and Ryuhei Tanaka and Kenji Muraoka and Yasuhiro Ebihara and Kazuya Ikebuchi and Kiyoshi Yasukawa and Tetsuya Taga and Tadamitsu Kishimoto and Tatsutoshi Nakahata},
  journal={The Journal of Experimental Medicine},
  year={1996},
  volume={183},
  pages={837 - 845}
}
Erythropoietin (EPO) is the primary humoral regulator of erythropoiesis and no other factor has previously been reported to support proliferation and terminal maturation of erythroid cells from hemopoietic stem cells. Here we show that stimulation of glycoprotein (gp130) by a combination of recombinant human soluble interleukin 6 receptor (sIL-6R) and IL-6 but not sIL-6R or IL-6 alone can support proliferation, differentiation, and terminal maturation of erythroid cells in the absence of EPO… CONTINUE READING

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