Erythropoietin in combination of tissue plasminogen activator exacerbates brain hemorrhage when treatment is initiated 6 hours after stroke.

Abstract

BACKGROUND AND PURPOSE Erythropoietin (EPO), a hematopoietic cytokine, exerts neuroprotective effects in experimental stroke. In the present study, we investigated the effect of recombinant human EPO (rhEPO) in combination with tissue plasminogen activator (tPA) on embolic stroke. METHODS Rats subjected to embolic middle cerebral artery occlusion (MCAO… (More)
DOI: 10.1161/STROKEAHA.110.586198

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