Erythropoietin in Human Milk: Physiology and Role in Infant Health

@article{Semba2002ErythropoietinIH,
  title={Erythropoietin in Human Milk: Physiology and Role in Infant Health},
  author={R. Semba and S. Juul},
  journal={Journal of Human Lactation},
  year={2002},
  volume={18},
  pages={252 - 261}
}
Human milk contains substantial concentrations of erythropoietin, a hormone best known for its role in the regulation of erythropoiesis. Recent studies show that erythropoietin receptors are widely distributed in human tissues, including the gastrointestinal tract, endothelial cells, spinal cord, and brain, suggesting that erythropoietin plays a wider role in infant development. Mammary epithelial cells contribute to the production of erythropoietin in human milk, and erythropoietin… Expand
Pleiotropic functions of erythropoietin.
  • R. Sasaki
  • Biology, Medicine
  • Internal medicine
  • 2003
TLDR
The uterine EPO is likely involved in the estrogen-dependent angiogenesis of the endometrial layer, and the possible functions in other tissues and tissue-characteristic regulation of EPO production are discussed in this review. Expand
Erythropoietin: A Hormone with Multiple Functions
TLDR
A detailed insight is provided into the nonhemopoietic role of EPO and its mechanism(s) of action which may lead to a better understanding of its potential therapeutic value in diverse clinical settings. Expand
Antiinfective properties of human milk.
TLDR
The protection from infections may be ensured either passively by factors with antiinfective, hormonal, enzymatic, trophic, and bioactive activity present in breast milk, or through a modulator effect on the neonatal immune system exerted by cells, cytokines, and other immune agents in human milk. Expand
Antiinfective Properties of Human Milk 1 , 2
The unfavorable effects of neonatal immunodeficiency are limited by some naturally occurring compensatory mechanisms, such as the introduction of protective and immunological components of human milkExpand
Influence of Diet on Infection and Allergy in Infants Antiinfective Properties of Human Milk 1 , 2
The unfavorable effects of neonatal immunodeficiency are limited by some naturally occurring compensatory mechanisms, such as the introduction of protective and immunological components of human milkExpand
Insulin-like growth factors (IGFs), IGF binding proteins, and other endocrine factors in milk: role in the newborn.
TLDR
This chapter provides an overview of work conducted primarily in neonatal calves and secondarily in other species on the effects on neonates of selected peptide endocrine factors (hormones, growth factors, in part cytokines) in colostrum. Expand
Study on the Trophic Effect of Human Recombinant Erythropoietin on the Developing Small Bowel in Neonatal Rats
TLDR
Enteral administration of human recombinant Epo has a local trophic effect on small bowel, which is useful in treatment of infants suffering from defective absorption due to short bowel syndrome. Expand
Importance of Amniotic Fluid in Gastrointestinal Development
TLDR
The authors review the various functions of AF and its importance in fetal gastrointestinal tract development and possible future uses of this extremely important bioactive fluid. Expand
Human Milk: Its Components and Their Immunobiologic Functions
TLDR
The significant protection conferred by breast-feeding against varied infections such as acute and prolonged diarrhea, neonatal septicemia, respiratory tract infections, acute and recurrent otitis media, and urinary tract infections is observed worldwide. Expand
Amniotic fluid: Source of trophic factors for the developing intestine.
TLDR
The role of AF borne TF in the development of GIT is reviewed to assess the role of genetic preprogramming, local and systemic endocrine secretions and many trophic factors from swallowed AF contribute and modulate the development and growth of the GIT. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 161 REFERENCES
Origin and Fate of Erythropoietin in Human Milk
TLDR
Erythropoietin concentrations in milk increase as a function of the duration of breast feeding, that Epo is actively secreted into human milk by mammary duct epithelia, and that the Epo within milk is largely protected from digestion. Expand
Human Milk as a Potential Enteral Source of Erythropoietin
TLDR
It is concluded that human milk contains considerable amounts of Epo which resist degradation after exposure to gastric juices at physiologic pH levels, which support continued investigation into the fate and developmental roles of EpO in human milk. Expand
Erythropoietin levels and erythropoiesis at birth in infants with Potter syndrome.
TLDR
The purpose of the study was to determine whether blood and tissue levels of Ep and indicators of erythropoiesis are normal at birth in infants with severe congenital renal disease. Expand
Why Is Erythropoietin Present in Human Milk? Studies of Erythropoietin Receptors on Enterocytes of Human and Rat Neonates
TLDR
Recombinant Epo increases the rate of migration of IEC-6 cells and decreases cytokine-induced apoptosis, and suggests that Epo within human milk has actions on neonate's intestinal function. Expand
Erythropoietin acts as a trophic factor in neonatal rat intestine
TLDR
REpo is not enterally absorbed in an intact and functional form from the intestines of neonatal rat pups, and enterally dosed rEpo has no erythropoietic effects, however, rEPO acts as a trophic factor in developing rat small bowel whether given enterally or parenterally. Expand
Nonerythropoietic roles of erythropoietin in the fetus and neonate.
  • S. Juul
  • Medicine
  • Clinics in perinatology
  • 2000
TLDR
There are also promising data regarding rEpo as a possible neuroprotective agent in such conditions as hypoxia, because it decreases programmed cell death induced during such adverse conditions. Expand
Erythropoietin Levels in Cord Blood as an Indicator of Intrauterine Hypoxia
  • P. Finne
  • Medicine
  • Acta paediatrica Scandinavica
  • 1966
TLDR
The results indicate that both anemic and hypoxic hypoxia may give an increase in erythro‐poietin content, and that erythropoietin is a stimulating factor for red cell production in fetal life, at least in the last months. Expand
Neonatal erythropoiesis. I. Peripheral blood erythropoietic parameters: data suggest erythropoietin transfer via maternal milk.
In this study peripheral blood erythropoietic parameters in 9 to 12-day-old neonatal rats suckled by experimentally-induced anemic mothers were examined. Stimulation of erythropoiesis in these pupsExpand
Enteral Absorption of Erythropoietin in the Suckling Rat
Milk contains biologically relevant concentrations of erythropoietin (Epo), the primary hormone responsible for erythrocyte production. In animals, milk-borne Epo stimulates erythropoiesis. EpoExpand
FETAL AND NEONATAL ERYTHROPOIESIS *
TLDR
The evolution of the erythron and its regulation have been studied in the fetal and neonatal rat, which is a relatively immature animal in comparison with human beings at birth, and in the guinea pig, an animrl in which the degree of maturity at birth approaches that of the human being. Expand
...
1
2
3
4
5
...