Erythropoietin in Human Milk: Physiology and Role in Infant Health

@article{Semba2002ErythropoietinIH,
  title={Erythropoietin in Human Milk: Physiology and Role in Infant Health},
  author={Richard D. Semba and Sandra E. Juul},
  journal={Journal of Human Lactation},
  year={2002},
  volume={18},
  pages={252 - 261}
}
  • R. SembaS. Juul
  • Published 1 August 2002
  • Medicine, Biology
  • Journal of Human Lactation
Human milk contains substantial concentrations of erythropoietin, a hormone best known for its role in the regulation of erythropoiesis. Recent studies show that erythropoietin receptors are widely distributed in human tissues, including the gastrointestinal tract, endothelial cells, spinal cord, and brain, suggesting that erythropoietin plays a wider role in infant development. Mammary epithelial cells contribute to the production of erythropoietin in human milk, and erythropoietin… 

Figures from this paper

Pleiotropic functions of erythropoietin.

  • R. Sasaki
  • Medicine, Biology
    Internal medicine
  • 2003
The uterine EPO is likely involved in the estrogen-dependent angiogenesis of the endometrial layer, and the possible functions in other tissues and tissue-characteristic regulation of EPO production are discussed in this review.

Erythropoietin: A Hormone with Multiple Functions

A detailed insight is provided into the nonhemopoietic role of EPO and its mechanism(s) of action which may lead to a better understanding of its potential therapeutic value in diverse clinical settings.

Antiinfective properties of human milk.

The protection from infections may be ensured either passively by factors with antiinfective, hormonal, enzymatic, trophic, and bioactive activity present in breast milk, or through a modulator effect on the neonatal immune system exerted by cells, cytokines, and other immune agents in human milk.

Antiinfective Properties of Human Milk 1 , 2

The protection from infections may be ensured either passively by factors with antiinfective, hormonal, enzymatic, trophic, and bioactive activity present in breast milk, or through a modulator effect on the neonatal immune system exerted by cells, cytokines, and other immune agents in human milk.

Influence of Diet on Infection and Allergy in Infants Antiinfective Properties of Human Milk 1 , 2

The protection from infections may be ensured either passively by factors with antiinfective, hormonal, enzymatic, trophic, and bioactive activity present in breast milk, or through a modulator effect on the neonatal immune system exerted by cells, cytokines, and other immune agents in human milk.

Insulin-like growth factors (IGFs), IGF binding proteins, and other endocrine factors in milk: role in the newborn.

This chapter provides an overview of work conducted primarily in neonatal calves and secondarily in other species on the effects on neonates of selected peptide endocrine factors (hormones, growth factors, in part cytokines) in colostrum.

Study on the Trophic Effect of Human Recombinant Erythropoietin on the Developing Small Bowel in Neonatal Rats

Enteral administration of human recombinant Epo has a local trophic effect on small bowel, which is useful in treatment of infants suffering from defective absorption due to short bowel syndrome.

Importance of Amniotic Fluid in Gastrointestinal Development

The authors review the various functions of AF and its importance in fetal gastrointestinal tract development and possible future uses of this extremely important bioactive fluid.

Cellular and transcriptional diversity over the course of human lactation

The description of the cellular components of breast milk, their association with maternal-infant dyad metadata and quantification of alterations at the gene and pathways levels provides the first detailed longitudinal picture of human breast milk cells across lactational time.

References

SHOWING 1-10 OF 161 REFERENCES

Origin and Fate of Erythropoietin in Human Milk

Erythropoietin concentrations in milk increase as a function of the duration of breast feeding, that Epo is actively secreted into human milk by mammary duct epithelia, and that the Epo within milk is largely protected from digestion.

Human Milk as a Potential Enteral Source of Erythropoietin

It is concluded that human milk contains considerable amounts of Epo which resist degradation after exposure to gastric juices at physiologic pH levels, which support continued investigation into the fate and developmental roles of EpO in human milk.

Why Is Erythropoietin Present in Human Milk? Studies of Erythropoietin Receptors on Enterocytes of Human and Rat Neonates

Recombinant Epo increases the rate of migration of IEC-6 cells and decreases cytokine-induced apoptosis, and suggests that Epo within human milk has actions on neonate's intestinal function.

Erythropoietin acts as a trophic factor in neonatal rat intestine

REpo is not enterally absorbed in an intact and functional form from the intestines of neonatal rat pups, and enterally dosed rEpo has no erythropoietic effects, however, rEPO acts as a trophic factor in developing rat small bowel whether given enterally or parenterally.

Neonatal erythropoiesis. I. Peripheral blood erythropoietic parameters: data suggest erythropoietin transfer via maternal milk.

In this study peripheral blood erythropoietic parameters in 9 to 12-day-old neonatal rats suckled by experimentally-induced anemic mothers were examined. Stimulation of erythropoiesis in these pups

Enteral Absorption of Erythropoietin in the Suckling Rat

Milk contains biologically relevant concentrations of erythropoietin (Epo), the primary hormone responsible for erythrocyte production. In animals, milk-borne Epo stimulates erythropoiesis. Epo

FETAL AND NEONATAL ERYTHROPOIESIS *

The evolution of the erythron and its regulation have been studied in the fetal and neonatal rat, which is a relatively immature animal in comparison with human beings at birth, and in the guinea pig, an animrl in which the degree of maturity at birth approaches that of the human being.

Recombinant Human Erythropoietin: Possible Role as an Antioxidant in Premature Rabbits

It is proposed that by stimulating erythropoiesis, rhEPO mobilizes non-heme iron and decreases oxidant injury that depends on the availability of transient metal.

Cellular sites of extrarenal and renal erythropoietin production in anaemic rats

It is suggested that hepatocytes are the major source of extrarenal erythropoietin with nonparenchymal liver cells contributing less than 1% to total hepatic erythroietin production.

Isolation and characterization of genomic and cDNA clones of human erythropoietin

The cloning of the human erythropoietin gene and the expression of an erythrocytes cDNA clone in a transient mammalian expression system to yield a secreted product with biological activity are described.
...