Erythropoietin improves memory function with reducing endothelial dysfunction and amyloid-beta burden in Alzheimer's disease models.

@article{Lee2012ErythropoietinIM,
  title={Erythropoietin improves memory function with reducing endothelial dysfunction and amyloid-beta burden in Alzheimer's disease models.},
  author={Soon-Tae Lee and Kon Chu and Jung-eun Park and Keun-Hwa Jung and Daejong Jeon and Ji-youn Lim and Sang Kun Lee and Manho Kim and Jae-Kyu Roh},
  journal={Journal of neurochemistry},
  year={2012},
  volume={120 1},
  pages={
          115-24
        }
}
Neurovascular degeneration contributes to the pathogenesis of Alzheimer's disease (AD). Because erythropoietin (EPO) promotes endothelial regeneration, we investigated the therapeutic effects of EPO in animal models of AD. In aged Tg2576 mice, EPO receptors (EPORs) were expressed in the cortex and hippocampus. Tg2576 mice were treated with daily injection of EPO (5000 IU/kg/day) for 5 days. At 14 days, EPO improved contextual memory as measured by fear-conditioning test. EPO enhanced… CONTINUE READING

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