Erythropoietin-dependent erythropoiesis: New insights and questions.

  title={Erythropoietin-dependent erythropoiesis: New insights and questions.},
  author={Don M. Wojchowski and Madhu P Menon and Pradeep Sathyanarayana and Jing Fang and Vinit Karur and Estelle Houde and William S. Kapelle and Oleg Bogachev},
  journal={Blood cells, molecules & diseases},
  volume={36 2},
Committed erythroid progenitor cells require exposure to erythropoietin (Epo) for their survival and for their quantitatively regulated transition to red blood cells. With regard to Epo signal transduction mechanisms, much has been learned from analyses in cell line models, fetal liver or spleen-derived primary erythroblasts and human CD34pos progenitor cells from cord blood or mobilized bone marrow. Presently, we have developed an ex vivo system that efficiently supports the expansion and… CONTINUE READING
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