Erythropoietin and the nervous system

@article{Genc2004ErythropoietinAT,
  title={Erythropoietin and the nervous system},
  author={S. Genc and Tolga F Koroglu and K. Genc̨},
  journal={Brain Research},
  year={2004},
  volume={1000},
  pages={19-31}
}
Erythropoietin (Epo) is a hematopoietic growth factor and cytokine which stimulates erythropoiesis. In recent years, Epo has been shown to have important nonhematopoietic functions in the nervous system. Nonerythropoietic actions of Epo include a critical role in the development, maintenance, protection and repair of the nervous system. A wide variety of experimental studies have shown that Epo and its receptor are expressed in the nervous system and Epo exerts remarkable neuroprotection in… Expand
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The hypoxiainduced production of EPO in the adult brain suggests that it could exert a neurotropic and neuroprotective effect in case of brain injury, and the possibility that human recombinant EPO therapy could soon be used in clinical practice to limit the neuronal damage induced by different disease. Expand
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Evidence for potential Epo receptors that might mediate Epo’s tissue-protective function in non-hematopoietic tissue is summarized, with focus on the nervous system. Expand
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acid (~30 kDa) glycoprotein that belongs to the cytokine type I superfamily. Originally, it was believed that the only role of Epo was the regulation of erythropoiesis. This role is attributed to theExpand
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TLDR
It is concluded that Epo may exert a modulatory action on GABAergic transmission in developing neural networks via the specific membrane receptor (EpoR) via miniature IPSCs. Expand
Erythropoietin and respiratory control at adulthood and during early postnatal life
  • J. Soliz
  • Medicine
  • Respiratory Physiology & Neurobiology
  • 2013
TLDR
The objective of this review is to summarize the role and mode of action of Epo on respiratory control in adult mammals and highlight the potential pathways by which this cytokine achieve this function. Expand
Expression and function of erythropoietin and its receptor in invertebrate nervous systems
TLDR
The results of the doctoral studies indicate that a ligand/receptor system similar to the vertebrate EPO/EPOR signalling system is expressed in the nervous systems of invertebrates. Expand
Extra-Hematopoietic Action of Erythropoietin
TLDR
Recombinant human EPO has been shown to protect the heart and the brain against ischemia or is chemia-reperfusion injury through antiapoptosis, anti-inflammation, EPC recruitment, and neovascularization. Expand
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