Erythropoietin and the nervous system

  title={Erythropoietin and the nervous system},
  author={Şermin Genç and Tolga F Koroglu and Kursad Genc},
  journal={Brain Research},

Neuroprotection by Erythropoietin - A Review

The hypoxiainduced production of EPO in the adult brain suggests that it could exert a neurotropic and neuroprotective effect in case of brain injury, and the possibility that human recombinant EPO therapy could soon be used in clinical practice to limit the neuronal damage induced by different disease.

Alternative Erythropoietin Receptors in the Nervous System

Evidence for potential Epo receptors that might mediate Epo’s tissue-protective function in non-hematopoietic tissue is summarized, with focus on the nervous system.

Expression of Erythropoietin and Its Receptor in the Central Nervous System

Erythropoietin (EPO) is a glycoprotein that is produced mainly by interstitial fibroblasts in the kidney. Released into the circulation, EPO makes its way to the bone marrow where it regulates red


Erythropoietin (EPO) is a glycoprotein that is produced mainly by interstitial fibroblasts in the kidney. Released into the circulation, EPO makes its way to the bone marrow where it regulates red

Cardiovascular effects of erythropoietin an update.

Brain Protection by Erythropoietin : A Manifold Task Tamer Rabie

A novel cytoprotective effect of Epo was established in several organs and it showed protection in various myocardial ischemia models, and the following review will concentrate on the effects of EpO in the brain.

Erythropoietin affects GABAergic transmission in hippocampal neurons in vitro

It is concluded that Epo may exert a modulatory action on GABAergic transmission in developing neural networks via the specific membrane receptor (EpoR) via miniature IPSCs.

Erythropoietin and respiratory control at adulthood and during early postnatal life

  • J. Soliz
  • Biology
    Respiratory Physiology & Neurobiology
  • 2013

Expression and function of erythropoietin and its receptor in invertebrate nervous systems

The results of the doctoral studies indicate that a ligand/receptor system similar to the vertebrate EPO/EPOR signalling system is expressed in the nervous systems of invertebrates.



Erythropoietin in the central nervous system, and its use to prevent hypoxic‐ischemic brain damage

  • S. Juul
  • Biology
    Acta paediatrica (Oslo, Norway : 1992). Supplement
  • 2002
Epo has been identified as a neurotrophic and neuroprotective agent in a wide variety of experimental paradigms, from neuronal cell culture to in vivo models of brain injury, and has direct antioxidant effects.

Identification of a neurotrophic sequence in erythropoietin.

Findings indicate that neural cells and not hematological cells respond to a peptide sequence within erythropoietin and suggests that Epo may have separate domains for neurotrophic and hematotrophic function.

Erythropoietin and Erythropoietin Receptor in the Developing Human Central Nervous System

Protein and mRNA for Epo and its receptor are expressed by human neurons and glial cells in spinal cord and brain during fetal development and these receptors appear to have a neuroprotective effect in conditions of hypoxia.

Erythropoietin induces changes in gene expression in PC-12 cells.

Erythropoietin and Erythropoietin Receptors in Human CNS Neurons, Astrocytes, Microglia, and Oligodendrocytes Grown in Culture

The results suggest that proinflammatory cytokines regulate expression of EPO and EPOR in human neurons, astrocytes, and microglia and further facilitate interactions among different cell types in the human CNS.

Physiology and function of the erythropoietin receptor

The three-dimensional structure of the EPOR has been determined, and a biologically active 20 amino acid peptide has been shown to cause dimerization of the extracellular domain of EPOR.

A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes.

The results provide a novel site of Epo production and suggest that Epo acts on neurons in a paracrine fashion, and the regulation of EpO production by oxygen operates at the level of its mRNA.

Erythropoietin and erythropoietin receptors in the peripheral nervous system: changes after nerve injury

  • W. CampanaR. Myers
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2001
The results demonstrate the presence of both Epo and EpoR in the rat sciatic nerve and their regulation after painful nerve injury.

Effects of Erythropoietin on Neuronal Activity

The results suggest that EPO stimulates neuronal function and viability via activation of Ca2+ channels.