Erythropoietin and the hypoxic brain.

  title={Erythropoietin and the hypoxic brain.},
  author={Hugo H. Marti},
  journal={The Journal of experimental biology},
  volume={207 Pt 18},
  • Hugo H. Marti
  • Published 2004 in The Journal of experimental biology
Normal tissue function in mammals depends on adequate supply of oxygen through blood vessels. A discrepancy between oxygen supply and consumption (hypoxia) induces a variety of specific adaptation mechanisms at the cellular, local and systemic level. These mechanisms are in part governed by the activation of hypoxia-inducible transcription factors (HIF-1, HIF-2), which in turn modulate expression of hypoxically regulated genes such as those encoding vascular endothelial growth factor (VEGF) and… CONTINUE READING
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