Erythropoietin and the heart: facts and perspectives.

  title={Erythropoietin and the heart: facts and perspectives.},
  author={Vittoria Mastromarino and Massimo Volpe and Maria Beatrice Musumeci and Camillo Autore and Elena Conti},
  journal={Clinical science},
  volume={120 2},
EPO (erythropoietin) has long been identified as a primary regulator of erythropoiesis. Subsequently, EPO has been recognized as playing a role in a broad variety of processes in cardiovascular pathophysiology. In particular, the tight interactions of EPO with the nitric oxide pathway, apoptosis, ischaemia, cell proliferation and platelet activation appear of great interest. Although enhanced EPO synthesis is viewed as an appropriate compensatory mechanism in the cardio-renal syndrome, which… CONTINUE READING
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