Erythropoietin and erythropoietin receptor expression in head and neck cancer: relationship to tumor hypoxia.

@article{Arcasoy2005ErythropoietinAE,
  title={Erythropoietin and erythropoietin receptor expression in head and neck cancer: relationship to tumor hypoxia.},
  author={Murat O. Arcasoy and Khalid Mohamed Amin and Shu-Chuan Chou and Zishan A. Haroon and Mahesh A. Varia and James A. Raleigh},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 1},
  pages={20-7}
}
PURPOSE Erythropoietin, an oxygen-regulated glycoprotein hormone, is a hematopoietic cytokine that stimulates erythropoiesis by binding to its cellular receptor [erythropoietin receptor (EPOR)]. The recombinant form of human erythropoietin is used to prevent or treat anemia in cancer patients. However, in a recent randomized, placebo-controlled trial involving patients receiving curative radiotherapy for squamous cell carcinoma of the head and neck, erythropoietin treatment was associated with… CONTINUE READING