Erythropoietin and Epidemiology of Alzheimer Disease

@article{Ismailov2013ErythropoietinAE,
  title={Erythropoietin and Epidemiology of Alzheimer Disease},
  author={R. M. Ismailov},
  journal={Alzheimer Disease \& Associated Disorders},
  year={2013},
  volume={27},
  pages={204–206}
}
  • R. M. Ismailov
  • Published 2013
  • Medicine
  • Alzheimer Disease & Associated Disorders
Alzheimer disease (AD) is a neurodegenerative disorder with a strong vascular component and the most frequent form of dementia. The cause of AD is still not well understood. A number of hypotheses have been developed, yet the cause is still unknown. For example, the amyloid hypothesis suggested that the deposit of the b-amyloid peptide can lead to cognitive decline as well as to disrupted cerebral blood flow.1 However, some research evidence showed that older individuals can have extensive… Expand

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References

SHOWING 1-10 OF 17 REFERENCES
Impaired cerebromicrovascular perfusion. Summary of evidence in support of its causality in Alzheimer's disease.
TLDR
CATCH supports the heterogeneic disease profile assumed to be characteristic of the AD syndrome and introduces a normal but potentially menacing process that lowers cerebral blood flow in proportion to increased aging. Expand
Impaired Cerebromicrovascular Perfusion: Summary of Evidence in Support of Its Causality in Alzheimer's Disease
Abstract: After nearly a century of inquiry, the cause of Alzheimer's disease (AD) remains to be found. In this review, basic and clinical evidence is presented that assembles and hypotheticallyExpand
Amyloid deposition as the central event in the aetiology of Alzheimer's disease.
TLDR
The recent discovery of a pathogenic mutation in the beta-amyloid precursor protein (APP) gene on chromosome 21 suggests that APP Mismetabolism and beta-amide deposition are the primary events in the disease process. Expand
Alzheimer neuropathologic alterations in aged cognitively normal subjects.
TLDR
It is demonstrated that the brains of a large percentage of cognitively normal, relatively well-educated individuals contain numerous degenerative changes and only a small percentage are relatively free of these changes. Expand
Improvement of cognitive functions in chronic schizophrenic patients by recombinant human erythropoietin
TLDR
Patients receiving rhEPO showed a significant improvement over placebo patients in schizophrenia-related cognitive performance (RBANS subtests, WCST-64), but no effects on psychopathology or social functioning. Expand
The role of erythropoietin in the "stroke belt" phenomenon.
TLDR
It is hypothesized that this nonrandom stroke distribution is related to regional differences in individual levels of erythropoietin (EPO), a hormone, which production depends on the tissue hypoxia due to variation in altitude. Expand
Erythropoietin reduces perihematomal inflammation and cell death with eNOS and STAT3 activations in experimental intracerebral hemorrhage
TLDR
The data suggests that EPO treatment in ICH induces better functional recovery with reducing perihematomal inflammation and apoptosis, coupled with activations of eNOS, STAT3 and ERK. Expand
Angiogenesis and plasticity: role of erythropoietin in vascular systems.
TLDR
Recognition of the multipotential attributes of EPO for vascular systems may further the progress of the development of therapeutic strategies to delay the onset of degenerative diseases. Expand
The non‐haematopoietic biological effects of erythropoietin
  • M. Arcasoy
  • Biology, Medicine
  • British journal of haematology
  • 2008
TLDR
A series of recent studies suggest that endogenous Epo–EpoR signalling contributes to wound healing responses, physiological and pathological angiogenesis, and the body’s innate response to injury in the brain and heart. Expand
Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades
TLDR
It is shown that preconditioning with EPO protects neurons in models of ischaemic and degenerative damage due to excitotoxins and consequent generation of free radicals, including nitric oxide, and this EPO effect may underlie neuroprotection mediated by hypoxic–ischaemic preconditionsing. Expand
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