Erythropoietin and Cancer: The Unintended Consequences of Anemia Correction

@inproceedings{Debeljak2014ErythropoietinAC,
  title={Erythropoietin and Cancer: The Unintended Consequences of Anemia Correction},
  author={Nata{\vs}a Debeljak and Peter Sol{\'a}r and Arthur J. Sytkowski},
  booktitle={Front. Immunol.},
  year={2014}
}
Until 1990, erythropoietin (EPO) was considered to have a single biological purpose and action, the stimulation of red blood cell growth and differentiation. Slowly, scientific and medical opinion evolved, beginning with the discovery of an effect on endothelial cell growth in vitro and the identification of EPO receptors (EPORs) on neuronal cells. We now know that EPO is a pleiotropic growth factor that exhibits an anti-apoptotic action on numerous cells and tissues, including malignant ones… CONTINUE READING
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