Erythropoietin after a century of research: younger than ever
@article{Jelkmann2007ErythropoietinAA, title={Erythropoietin after a century of research: younger than ever}, author={Wolfgang Jelkmann}, journal={European Journal of Haematology}, year={2007}, volume={78} }
In the light of the enthusiasm regarding the use of recombinant human erythropoietin (Epo) and its analogues for treatment of the anaemias of chronic renal failure and malignancies it is worth remembering that today's success has been based on a century of laborious research. The concept of the humoral regulation of haematopoiesis was first formulated in 1906. The term ‘erythropoietin’ for the erythropoiesis‐stimulating hormone was introduced in 1948. Native human Epo was isolated in 1977 and…
364 Citations
[Erythropoietin - state of science].
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After a century of research and medical use, erythropoietin (EPO) has more therapeutic approaches than ever in history and its analogues are mainly used for treatment of the anaemias of chronic renal failure and malignancies.
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The regulation of erythropoietin production and its functions, as well as treatment approach for anaemia of chronic kidney disease, with particular focus on new therapies are reviewed.
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EPO has been abused by athletes participating in endurance sports and detecting this has proved to be a challenge, so its efficacy in stimulating erythropoiesis is dose dependent and differs according to the patient's disease and nutritional status.
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Erythropoietin is an endogenous growth factor that is required for erythropoiesis. The hormone consists of a single acidic polypeptide chain of 165 amino acids and three N-linked and one O-linked…
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A careful gathering of Epo/EpoR biomolecular information enabled us to assemble an unexpected jigsaw puzzle which could explain most of the controversies of preclinical and clinical studies.
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