Erythropoietin administration is associated with short-term improvement in glomerular filtration rate after ischemia-reperfusion injury.

@article{Slling2011ErythropoietinAI,
  title={Erythropoietin administration is associated with short-term improvement in glomerular filtration rate after ischemia-reperfusion injury.},
  author={Christoffer S\olling and Anton Tedja Christensen and S\oren Krag and J\orgen Fr\okiaer and L. D. Wogensen and Jan Krog and Else Kirstine T\onnesen},
  journal={Acta anaesthesiologica Scandinavica},
  year={2011},
  volume={55 2},
  pages={185-95}
}
BACKGROUND Erythropoietin (EPO) is a cytokine with organ-protective properties. We hypothesized that EPO could attenuate acute renal dysfunction and inflammation in a porcine model of ischemia-reperfusion (IR). Furthermore, we aimed to characterize the impact of EPO on systemic and renal hemodynamics, and renal oxygen consumption. METHODS Twenty-four pigs were randomly assigned to three groups: (1) EPO (5000 IU/kg) administered intravenously before IR (n=9), (2) placebo administered before IR… CONTINUE READING

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