Erythropoietin Stimulates Normal Endothelial Progenitor Cell-Mediated Endothelial Turnover, but Attributes to Neovascularization Only in the Presence of Local Ischemia

@article{Westenbrink2008ErythropoietinSN,
  title={Erythropoietin Stimulates Normal Endothelial Progenitor Cell-Mediated Endothelial Turnover, but Attributes to Neovascularization Only in the Presence of Local Ischemia},
  author={B. Daan Westenbrink and Hisko Oeseburg and Lennaert Kleijn and Pim van der Harst and Anne Belonje and Adriaan Alexander Voors and Regien Geertruida Schoemaker and Rudolf A. de Boer and Dirk Jan van Veldhuisen and Wiek H. van Gilst},
  journal={Cardiovascular Drugs and Therapy},
  year={2008},
  volume={22},
  pages={265-274}
}
We aimed to evaluate whether ischemia is required for erythropoietin (EPO) induced stimulation of endothelial progenitor cells (EPCs) and their related effects on endothelial and cardiac function. Bone marrow of rats was replaced by transgenic cells to allow tracking of EPCs. Ischemic heart failure was induced by left coronary artery ligation to induce myocardial infarction (MI) and control rats received a sham procedure. Three weeks after surgery, rats were randomized to receive EPO… CONTINUE READING
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