Erythropoietin Selectively Attenuates Cytokine Production and Inflammation in Cerebral Ischemia by Targeting Neuronal Apoptosis

@article{Villa2003ErythropoietinSA,
  title={Erythropoietin Selectively Attenuates Cytokine Production and Inflammation in Cerebral Ischemia by Targeting Neuronal Apoptosis},
  author={Pia Villa and Paolo Bigini and Tiziana Mennini and Davide Agnello and Teresa Laragione and Alfredo Cagnotto and Barbara Viviani and Marina Marinovich and Anthony Cerami and Thomas R. Coleman and Michael Brines and Pietro Ghezzi},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={198},
  pages={971 - 975}
}
Ischemic brain injury resulting from stroke arises from primary neuronal losses and by inflammatory responses. Previous studies suggest that erythropoietin (EPO) attenuates both processes. Although EPO is clearly antiapoptotic for neurons after experimental stroke, it is unknown whether EPO also directly modulates EPO receptor (EPO-R)-expressing glia, microglia, and other inflammatory cells. In these experiments, we show that recombinant human EPO (rhEPO; 5,000 U/kg body weight, i.p.) markedly… CONTINUE READING
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