Erythropoietin Receptor Activation Protects the Kidney From Ischemia/Reperfusion-Induced Apoptosis by Activating ERK/p53 Signal Pathway.

@article{Zou2016ErythropoietinRA,
  title={Erythropoietin Receptor Activation Protects the Kidney From Ischemia/Reperfusion-Induced Apoptosis by Activating ERK/p53 Signal Pathway.},
  author={Y-R Zou and Jianquan Zhang and Juan Wang and Longfei Peng and G Li and Li Wang},
  journal={Transplantation proceedings},
  year={2016},
  volume={48 1},
  pages={217-21}
}
BACKGROUND Apoptosis plays an important role in renal ischemia/reperfusion (IR) injury. Evidence has shown that erythropoietin (EPO) has an antiapoptotic effect. Therefore, this study aimed to explore the effect and potential mechanism of EPO in renal IR injury. METHODS Kidney IR injury in rats was established by clamping the left renal artery for 30 minutes followed by 24 hours of reperfusion, along with contralateral nephrectomy. Renal function, renal histology, and expression of EPOR, p… CONTINUE READING