Erythropoietin: physiology and pharmacology update.

@article{Fisher2003ErythropoietinPA,
  title={Erythropoietin: physiology and pharmacology update.},
  author={James W. Fisher},
  journal={Experimental biology and medicine},
  year={2003},
  volume={228 1},
  pages={
          1-14
        }
}
This minireview is an update of a 1997 review on erythropoietin (EPO) in this journal. EPO is a 30,400-dalton glycoprotein that regulates red cell production. In the human, EPO is produced by peritubular cells in the kidneys of the adult and in hepatocytes in the fetus. Small amounts of extra-renal EPO are produced by the liver in adult human subjects. EPO binds to an erythroid progenitor cell surface receptor that includes a p66 chain, and, when activated, the p66 protein becomes dimerized… CONTINUE READING

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