Erythropoiesis in the absence of janus-kinase 2: BCR-ABL induces red cell formation in JAK2(-/-) hematopoietic progenitors.

@article{Ghaffari2001ErythropoiesisIT,
  title={Erythropoiesis in the absence of janus-kinase 2: BCR-ABL induces red cell formation in JAK2(-/-) hematopoietic progenitors.},
  author={Saghi Ghaffari and Claire Kitidis and Mark D Fleming and Hans J Neubauer and Klaus Pfeffer and Harvey F. Lodish},
  journal={Blood},
  year={2001},
  volume={98 10},
  pages={
          2948-57
        }
}
The receptor-associated protein tyrosine kinase janus-kinase 2 (JAK2) is essential for normal red cell development and for erythropoietin receptor (EpoR) signaling. JAK2(-/-) embryos are severely deficient in erythropoiesis and die at an early stage of development from fetal anemia. The binding of erythropoietin (Epo) to the EpoR triggers the activation of JAK2, the phosphorylation of the EpoR, and the initiation of the EpoR signaling cascade. In addition to Epo binding to its receptor… 
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