Erythropoiesis and myocardial energy requirements contribute to the hypermetabolism of childhood sickle cell anemia.

@article{Hibbert2006ErythropoiesisAM,
  title={Erythropoiesis and myocardial energy requirements contribute to the hypermetabolism of childhood sickle cell anemia.},
  author={Jacqueline M. Hibbert and Melissa Creary and Beatrice E. Gee and Iris D. Buchanan and Alexander Quarshie and Lewis L. Hsu},
  journal={Journal of pediatric gastroenterology and nutrition},
  year={2006},
  volume={43 5},
  pages={680-7}
}
OBJECTIVES We hypothesized that an elevated hemoglobin synthesis rate (SynHb) and myocardial oxygen consumption (MVO2) contribute to the excess protein and energy metabolism reported in children with sickle cell anemia. PATIENTS AND METHODS Twelve children (6-12 years old) with asymptomatic sickle cell and 9 healthy children matched for age and sex were studied. Measurements were whole-body protein turnover by [1-C]leucine, SynHb by [N]glycine, resting energy expenditure by indirect… CONTINUE READING
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