Erythropoiesis and Iron Sulfur Cluster Biogenesis

@inproceedings{Ye2010ErythropoiesisAI,
  title={Erythropoiesis and Iron Sulfur Cluster Biogenesis},
  author={Hong Ye and Tracey A Rouault},
  booktitle={Advances in hematology},
  year={2010}
}
Erythropoiesis in animals is a synchronized process of erythroid cell differentiation that depends on successful acquisition of iron. Heme synthesis depends on iron through its dependence on iron sulfur (Fe-S) cluster biogenesis. Here, we review the relationship between Fe-S biogenesis and heme synthesis in erythropoiesis, with emphasis on the proteins, GLRX5, ABCB7, ISCA, and C1orf69. These Fe-S biosynthesis proteins are highly expressed in erythroid tissues, and deficiency of each of these… CONTINUE READING
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