Erythromycin stimulates ileal motility by activation of dihydropyridine-sensitive calcium channels.

@article{Armstrong1992ErythromycinSI,
  title={Erythromycin stimulates ileal motility by activation of dihydropyridine-sensitive calcium channels.},
  author={David N. Armstrong and Garth H. Ballantyne and Irvin Mark Modlin},
  journal={The Journal of surgical research},
  year={1992},
  volume={52 2},
  pages={140-6}
}
Erythromycin, a macrolide antibiotic, is a potent stimulant of small bowel motor activity (MA) which may motility either via the peptide motilin receptor or neural mechanisms. We hypothesized that erythromycin stimulates directly stimulates smooth muscle cells by a calcium-mediated event. Thus, we evaluated the effect of neuronal blockade with tetrodotoxin, muscarinic blockade with atropine, and opiate blockade with naloxone on erythromycin-stimulated MA in isolated perfused segments of rabbit… CONTINUE READING