Erythromycin modulates IL-8 expression in normal and inflamed human bronchial epithelial cells.

@article{Takizawa1997ErythromycinMI,
  title={Erythromycin modulates IL-8 expression in normal and inflamed human bronchial epithelial cells.},
  author={Hajime Takizawa and Masashi Desaki and Takayuki Ohtoshi and Shin Ichi Kawasaki and Tadashi Kohyama and Makoto Sato and Masaki Tanaka and Tsuyoshi Kasama and Kanichiro Kobayashi and Jun Nakajima and Kazuhiro Ito},
  journal={American journal of respiratory and critical care medicine},
  year={1997},
  volume={156 1},
  pages={
          266-71
        }
}
Erythromycin (EM) and its 14-member macrolide analogues have attracted attention for its effectiveness in a variety of airway diseases, including diffuse panbronchiolitis (DPB), sinobronchial syndrome, and chronic sinusitis. However, its mechanisms of action remain unelucidated. We evaluated the effects of several antibiotics on IL-8 expression by normal and transformed human bronchial epithelial cells, an important source of this potent chemokine involved in cell recruitment into the airways… CONTINUE READING

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