Erythromycin intravenous bolus infusion in acute upper gastrointestinal bleeding: a randomized, controlled, double-blind trial.

@article{Frossard2002ErythromycinIB,
  title={Erythromycin intravenous bolus infusion in acute upper gastrointestinal bleeding: a randomized, controlled, double-blind trial.},
  author={Jean-Louis Frossard and Laurent Spahr and Pierre Edouard Queneau and Emiliano Giostra and B. -Ch. Burckhardt and Ga{\"e}lle Ory and Philippe P H de Saussure and Berj Armenian and Raymond de Peyer and Antoine Hadengue},
  journal={Gastroenterology},
  year={2002},
  volume={123 1},
  pages={17-23}
}
BACKGROUND & AIMS Emergency endoscopy may be difficult in upper gastrointestinal bleeding when blood obscures the visibility. Erythromycin, a motilin agonist, induces gastric emptying. We investigated whether an intravenous bolus infusion of erythromycin would improve the yield of endoscopy in these patients. METHODS Patients admitted within 12 hours after hematemesis were randomly assigned to erythromycin (250 mg) or placebo, 20 minutes before endoscopy. The primary end point was endoscopic… CONTINUE READING
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