Erythromycin increases plasma concentrations of alpha-dihydroergocryptine in humans.

@article{Mey2001ErythromycinIP,
  title={Erythromycin increases plasma concentrations of alpha-dihydroergocryptine in humans.},
  author={Christian de Mey and Michael Althaus and Eric Ezan and Angelika Retzow},
  journal={Clinical pharmacology and therapeutics},
  year={2001},
  volume={70 2},
  pages={142-8}
}
OBJECTIVE Our objective was to investigate the potential for relevant pharmacotherapeutic interaction between cytochrome P4503A4 (CYP3A4)-inhibiting agents such as erythromycin and the dopamine agonist alpha-dihydroergocryptine (DHEC). METHODS The study was carried out as a single-center, controlled, nonblinded, 2-way crossover clinical trial with randomly allocated period-balanced sequences, investigating two treatments of a single oral dose of 10 mg DHEC (on the morning of day 1), once… CONTINUE READING