Erythromycin‐felodipine interaction: Magnitude, mechanism, and comparison with grapefruit juice

@article{Bailey1996ErythromycinfelodipineIM,
  title={Erythromycin‐felodipine interaction: Magnitude, mechanism, and comparison with grapefruit juice},
  author={David G Bailey and John Richard Bend and J. Malcolm O. Arnold and Lan T. Tran and J. David Spence},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1996},
  volume={60}
}

Bergamottin contribution to the grapefruit juice–felodipine interaction and disposition in humans

Grapefruit juice–felodipine interaction in the elderly

Grapefruit juice can increase the oral bioavailability of a broad range of medications. This interaction has not been assessed in the elderly.

Grapefruit‐felodipine interaction: Effect of unprocessed fruit and probable active ingredients

To determine whether unprocessed grapefruit can cause a drug interaction, whether the active ingredients are naturally occurring, and whether specific furanocoumarins or flavonoids are involved, a study of grapefruit extract and its metabolites is conducted.

Seville orange juice‐felodipine interaction: Comparison with dilute grapefruit juice and involvement of furocoumarins

Our objective was to determine whether Seville orange juice produces a grapefruit juice–like interaction with felodipine and whether bergamottin, 6′,7′‐dihydroxybergamottin, or other furocoumarins

Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: Comparison with grapefruit juice

Effects of grapefruit juice on the pharmacokinetics of sildenafil

The influence of grapefruit juice, containing inhibitors of intestinal CYP3A4, on the pharmacokinetics of sildenafil and N‐desmethylsildenAFil is investigated.

Drug interactions with grapefruit: Whose responsibility is it to warn the public?

  • J. Spence
  • Psychology, Medicine
    Clinical pharmacology and therapeutics
  • 1997

Grapefruit: the last decade acquisitions.

...

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Grapefruit juice–felodipine interaction: Mechanism, predictability, and effect of naringin

Intersubject changes in felodipine and dehydrofelodipines AUC supported inhibition of both primary and secondary metabolic steps as a mechanism, and the interaction could not be predicted from baseline pharmacokinetics with water and did not result in more consistent bioavailability among individuals.

Grapefruit juice-felodipine interaction: reproducibility and characterization with the extended release drug formulation.

Felodipine 10 mg extended release was administered with 250 ml regular-strength grapefruit juice or water in a randomized crossover manner followed by a second grapefruit Juice treatment in 12 healthy men in a Random crossover manner to evaluate the pharmacokinetics of felodipne and primary oxidative metabolite, dehydrofelodipines, were evaluated.

A potentially hazardous interaction between erythromycin and midazolam

Metabolism of both erythromycin and midazolam by the same cytochrome P450IIIA isozyme may explain the observed pharmacokinetic interaction.

A potentially hazardous interaction between erythromycin and midazolam.

Metabolism of both erythromycin and midazolam by the same cytochrome P450IIIA isozyme may explain the observed pharmacokinetic interaction.

The first pass metabolism of nifedipine in man.

The peak plasma concentrations and area under the plasma concentration-time curve suggest that the nitropyridine analogue is a major, first pass, metabolite of nifedipine.