Erythromycin‐felodipine interaction: Magnitude, mechanism, and comparison with grapefruit juice

@article{Bailey1996ErythromycinfelodipineIM,
  title={Erythromycin‐felodipine interaction: Magnitude, mechanism, and comparison with grapefruit juice},
  author={D. Bailey and J. Bend and J. M. Arnold and L. T. Tran and J. Spence},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1996},
  volume={60}
}
To investigate a potentially marked effect by erythromycin on felodipine pharmacokinetics, to characterize the mechanism, and to compare the interaction with that between grapefruit juice and felodipine. 
Bergamottin contribution to the grapefruit juice–felodipine interaction and disposition in humans
Our objectives were to evaluate the contribution of bergamottin to the grapefruit juice–felodipine interaction and to characterize bergamottin disposition.
Grapefruit juice–felodipine interaction in the elderly
Grapefruit juice can increase the oral bioavailability of a broad range of medications. This interaction has not been assessed in the elderly.
Grapefruit‐felodipine interaction: Effect of unprocessed fruit and probable active ingredients
TLDR
To determine whether unprocessed grapefruit can cause a drug interaction, whether the active ingredients are naturally occurring, and whether specific furanocoumarins or flavonoids are involved, a study of grapefruit extract and its metabolites is conducted. Expand
Seville orange juice‐felodipine interaction: Comparison with dilute grapefruit juice and involvement of furocoumarins
Our objective was to determine whether Seville orange juice produces a grapefruit juice–like interaction with felodipine and whether bergamottin, 6′,7′‐dihydroxybergamottin, or other furocoumarinsExpand
Grapefruit juice—felodipine interaction: Effect of naringin and 6′,7′‐dihydroxybergamottin in humans
TLDR
To test whether naringin or 6′,7′‐dihydroxybergamottin is a major active substance in grape‐fruit juice‐felodipine interaction in humans, a large number of experiments have shown positive results. Expand
Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: Comparison with grapefruit juice
  • David G. Bailey, G. Dresser, J. Bend
  • Chemistry, Medicine
  • Clinical pharmacology and therapeutics
  • 2003
TLDR
Assessment of the importance of bergamottin in drug interactions through comparisons between grapefruit juice and lime juice and the potential for drug interactions with red wine found it to be important. Expand
Itraconazole greatly increases plasma concentrations and effects of felodipine
TLDR
Itraconazole strongly interacts with some of the substrates of CYP3A4 (e.g., terfenadine, triazolam and lovastatin); hence it is important to uncover the possible interaction of itraconAZole with felodipine. Expand
Effects of grapefruit juice on the pharmacokinetics of sildenafil
TLDR
The influence of grapefruit juice, containing inhibitors of intestinal CYP3A4, on the pharmacokinetics of sildenafil and N‐desmethylsildenAFil is investigated. Expand
Drug interactions with grapefruit: Whose responsibility is it to warn the public?
  • J. Spence
  • Medicine
  • Clinical pharmacology and therapeutics
  • 1997
TLDR
It is necessary to select patients suitable for vaginal or laparoscopic mesh placement for intranasal administration based on prior history and once they provide informed consent for surgery. Expand
Grapefruit: the last decade acquisitions.
TLDR
The bioavailability of many drugs was tested with grapefruit juice (GJ) coadministration; the inhibition on cytochrome P450 seems due to a synergic action between flavonoids and coumarins. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 32 REFERENCES
Interaction between grapefruit juice and midazolam in humans
TLDR
To investigate the effects of grapefruit juice on the pharmacokinetics and dynamics of midazolam, a new grapefruit-based formulation of the drug is developed. Expand
Disposition of intravenous and oral cyclosporine after administration with grapefruit juice
TLDR
To examine the effect of grapefruit juice on the disposition of cyclosporine after administration of oral and intravenous doses to healthy male subjects, grapefruit Juice is used as a raw material for the drug conjugation test. Expand
Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice
Grapefruit juice increases the bioavailability of several drugs known to be metabolized by CYP3A enzymes. Ketoconazole and itraconazole can increase the area under the concentration‐time curveExpand
Grapefruit juice–felodipine interaction: Mechanism, predictability, and effect of naringin
TLDR
Intersubject changes in felodipine and dehydrofelodipines AUC supported inhibition of both primary and secondary metabolic steps as a mechanism, and the interaction could not be predicted from baseline pharmacokinetics with water and did not result in more consistent bioavailability among individuals. Expand
Interaction of citrus juices with felodipine and nifedipine
TLDR
Six men with borderline hypertension took felodipine 5 mg with water, grapefruit juice, or orange juice; the bioavailability with grapefruit Juice was lower, diastolic blood pressure lower, and heart rate higher with Grapefruit juice than with water. Expand
Grapefruit juice-felodipine interaction: reproducibility and characterization with the extended release drug formulation.
TLDR
Felodipine 10 mg extended release was administered with 250 ml regular-strength grapefruit juice or water in a randomized crossover manner followed by a second grapefruit Juice treatment in 12 healthy men in a Random crossover manner to evaluate the pharmacokinetics of felodipne and primary oxidative metabolite, dehydrofelodipines, were evaluated. Expand
First-pass metabolism of cyclosporin by the gut
TLDR
These findings indicate that the small intestine is a major site of cyclosporin breakdown: such intestinal metabolism might help to explain the poor oral bioavailability and drug interactions of cyclOSporin. Expand
A potentially hazardous interaction between erythromycin and midazolam
TLDR
Metabolism of both erythromycin and midazolam by the same cytochrome P450IIIA isozyme may explain the observed pharmacokinetic interaction. Expand
A potentially hazardous interaction between erythromycin and midazolam.
TLDR
Metabolism of both erythromycin and midazolam by the same cytochrome P450IIIA isozyme may explain the observed pharmacokinetic interaction. Expand
The first pass metabolism of nifedipine in man.
TLDR
The peak plasma concentrations and area under the plasma concentration-time curve suggest that the nitropyridine analogue is a major, first pass, metabolite of nifedipine. Expand
...
1
2
3
4
...