Erythromelalgia: new theories and new therapies.

  title={Erythromelalgia: new theories and new therapies.},
  author={J. Solis Cohen},
  journal={Journal of the American Academy of Dermatology},
  volume={43 5 Pt 1},
  • J. S. Cohen
  • Published 1 November 2000
  • Medicine, Psychology
  • Journal of the American Academy of Dermatology
Erythromelalgia is a rare condition that has remained an enigma diagnostically and therapeutically for decades. It has been assumed that erythromelalgia, which is characterized by hot, red, intensely painful feet or hands, may be the opposite of Raynaud's phenomenon. However, new research suggests that these two disorders are more similar than dissimilar. Erythromelalgia usually follows a chronic, sometimes progressive and disabling course. New evidence suggests that this may not be a disease… 

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Coexistence of erythromelalgia and Raynaud's phenomenon.
Erythromelalgia: a case report and literature review.
Despite multiple treatment options, erythromelalgia is a challenging disease to effectively manage and early recognition and treatment may offer patients the best probability of achieving remission or significant improvement.
A Rare Case of Erythromelalgia in a Young Male Patient
This case report presents a young male patient, who has been diagnosed with erythromelalgia which is believed to be secondary to his Type 1 Diabetes Mellitus, which has diagnostic value for clinicians who have not seen this disorder.
Erythromelalgia With Subsequent Digital Necrosis, Glomerulonephritis, and Antiphospholipid Antibodies
The first reported case of erythromelalgia in a young woman with digital necrosis and mesangial nephritis associated with antiphospholipid antibodies is described and the differential diagnosis of this entity is discussed.
Primary erythromelalgia: case report.
It is reported the case of an eighteen-year-old male who presented, at the early age of two, development of the symptoms of erythema, heat and pain followed by desquamation of hands and feet, in outbreaks, with intervals 4 to 5 years long between the crises.
A Case of Erythromelalgia: Good Response to Combination Treatment with Pregabalin and Selective Serotonin Reuptake Inhibitor
A case of erythromelalgia, secondary to type 2 diabetes mellitus, is presented, with a good response to treatment with a combination of selective serotonin reuptake inhibitors and pregabalin.
Simvastatin-induced erythromelalgia: less is more
A case of a woman with uncomplicated Type 2 diabetes mellitus, presenting with severe burning pains and intense redness of the legs, for which only cooling could provide relief, where empirical discontinuation of simvastatin made all symptoms disappear.
Two Cases of Secondary Erythromelalgia Associated with Essential Hypertension
Two cases of secondary erythromelalgia associated with essential hypertension are reported, including a 22-year-old male soldier presented with paroxysmal redness of the both feet associated with pain and tenderness upon heat stimulation.
Sympathetic Block for Treating Primary Erythromelalgia
The case of a 12-year old girl with primary erythromelalgia in both lower extremities is reported, where a bilateral sympathetic block with lidocaine and triamcinolone resulted in relief from the pain.
Erythromelalgia: a cutaneous manifestation of neuropathy?*
This review is to be an update of the specialized bibliography of Erythromelalgia, an infrequent episodic acrosyndrome affecting mainly both lower limbs symmetrically with the classic triad of erythema, warmth and burning pain.


Refractory idiopathic erythromelalgia.
The following two case reports of idiopathic erythromelalgia in adolescent males demonstrate the need for aggressive techniques to manage the extraordinary pain symptomatology seen in these patients through the use of an Ice Cold.
[Erythromelalgia: a familial case. Discussion on the role of mercury].
A case of erythromelalgia observed in a 4-year-old girl, her father and her younger sister, particular due to an association with mercury poisoning is reported, suggesting X-linked dominant transmission.
[Familial erythermalgia treated with pizotifen].
Pizotifene, an antiserotoninergic drug proved to be effective in mother and 14-year-old child who had never drawn benefit from any previous treatment of erythermalgia, and deserves to be considered as a valuable possibility.
Erythromelalgia associated with acute diabetic neuropathy: an unusual condition.
The favourable evolution of the patient after treatment with aspirin and methysergide is described, suggesting a disorder in vascular motility regulation favored by the severe neuropathy, without being able to discount a possible immunomediated mechanism.
Erythromelalgia unmasked during norephedrine therapy: a case report.
The observations suggest that an enhanced vasodilatation due to an abnormal adrenergic sensitivity may play an important role in the pathogenesis of primary erythromelalgia, and continuous drug therapy with norephedrine may have led to adaptive adrenergic subsensitivity of vascular smooth muscles.
Erythromelalgia associated with hypertension and leukocytoclastic vasculitis in a child.
A case of erythromelalgia presenting with leukocytoclastic vasculitis and hypertension in a 7-year-old child who responded to therapy with prednisolone and phenoxybenzamine is described.
A way to understand erythromelalgia.
Erythromelalgia pain managed with gabapentin.
Two patients for whom several previously described treatments for the pain of erythromelalgia were ineffective and whose symptoms resolved after the institution of therapy with gabapentin are reported.
Erythromelalgia: response to serotonin reuptake inhibitors.
Erythromelalgia following influenza vaccine in a child.
A case of erythromelalgia which developed in a 4.5 year old girl following influenza vaccination is described, and low dose aspirin, carbamazepine and propranolol induced a rapid resolution of the syndrome.