Erythroleukemia induction by replication-competent type C viruses cloned from the anemia- and polycythemia-inducing isolates of Friend leukemia virus

@article{MacDonald1980ErythroleukemiaIB,
  title={Erythroleukemia induction by replication-competent type C viruses cloned from the anemia- and polycythemia-inducing isolates of Friend leukemia virus},
  author={M. MacDonald and T. Mak and A. Bernstein},
  journal={The Journal of Experimental Medicine},
  year={1980},
  volume={151},
  pages={1493 - 1503}
}
In this study, the biological properties of the replication-competent viruses, F-MuLVA, present in the anemia-inducing isolate of Friend leukemia virus complex (FV-A); and F-MuLVP, present in the polycythemia- inducing isolate of Friend leukemia virus complex (FV-P) have been examined. BALB/c mice infected as newborns with clonal isolates of F- MuLVA or F-MuLVP become anemic and show splenic enlargement characterized by an increased proportion of cells that resemble immature nucleated erythroid… Expand
47 Citations
Anemia- and polycythemia-inducing isolates of Friend spleen focus- forming virus. Biological and molecular evidence for two distinct viral genomes
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