Erythrocytic ATP release in the presence of modified cell-free hemoglobin.

Abstract

The red blood cell (RBC) has been proposed as an O(2) sensor through a direct link between the desaturation of intracellular hemoglobin (Hb) and ATP release, leading to vasodilation. We hypothesized that the addition of cell-free Hb to the extracellular space provides a supplementary O(2) source that reduces RBC desaturation and, consequently, ATP release… (More)
DOI: 10.1016/j.bpc.2009.07.004

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