Erythrocytes store and release sphingosine 1-phosphate in blood.

  title={Erythrocytes store and release sphingosine 1-phosphate in blood.},
  author={Petra H{\"a}nel and Paul Andr{\'e}ani and Markus H. Graeler},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={21 4},
The blood constituent sphingosine 1-phosphate (S1P) is a specific ligand for five G-protein-coupled receptors designated S1P(1-5). Expression of the S1P1 receptor on lymphocytes is required for their exit from secondary lymphoid organs, suggesting that S1P serves as a stimulus for maintaining lymphocyte circulation in blood. Despite its potential role in immune surveillance, the regulatory system that controls blood S1P levels is not well understood. This report reveals that erythrocytes… CONTINUE READING
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