Erythrocytes, leukocytes and platelets as a source of oxidative stress in chronic vascular diseases: detoxifying mechanisms and potential therapeutic options.

@article{MartinVentura2012ErythrocytesLA,
  title={Erythrocytes, leukocytes and platelets as a source of oxidative stress in chronic vascular diseases: detoxifying mechanisms and potential therapeutic options.},
  author={Jos{\'e}-Luis Martin-Ventura and Julio Madrigal-Matute and Roxana Mart{\'i}nez-Pinna and Priscila Ramos-Mozo and Lu{\'i}s Miguel Blanco-Colio and Juan Antonio Moreno and Carlos A. Tarin and Elena Burillo and Carlos Ernesto Fernandez-Garcia and Jes{\'u}s Egido and Olivier Meilhac and Jean-Baptiste Michel},
  journal={Thrombosis and haemostasis},
  year={2012},
  volume={108 3},
  pages={435-42}
}
Oxidative stress is involved in the chronic pathological vascular remodelling of both abdominal aortic aneurysm and occlusive atherosclerosis. Red blood cells (RBCs), leukocytes and platelets present in both, aneurysmal intraluminal thrombus and intraplaque haemorraghes, could be involved in the redox imbalance inside diseased arterial tissues. RBCs haemolysis may release the pro-oxidant haemoglobin (Hb), which transfers heme to tissue and low-density lipoproteins. Heme-iron potentiates… CONTINUE READING

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References

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Showing 1-10 of 101 references

In vitro and in vivo evidence for the role of elastase shedding of CD163 in human atherothrombosis

  • JA Moreno
  • Eur Heart J
  • 2012
1 Excerpt

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

  • PD Ray
  • Cell Signal 2012;
  • 2012
1 Excerpt

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