Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3.

@article{Yang2001ErythrocyteWP,
  title={Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3.},
  author={Baoxue Yang and Tonghui Ma and Alan S. Verkman},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 1},
  pages={624-8}
}
Aquaporin (AQP) water channel AQP3 has been proposed to be the major glycerol and non-AQP1 water transporter in erythrocytes. AQP1 and AQP3 are also expressed in the kidney where their deletion in mice produces distinct forms of nephrogenic diabetes insipidus. Here AQP1/AQP3 double knockout mice were generated and analyzed to investigate the functional role of AQP3 in erythrocytes and kidneys. 53 double knockout mice were born out of 756 pups from breeding double heterozygous mice. The double… CONTINUE READING
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