Erythrocyte protoporphyrin in experimental chronic lead poisoning in calves.

Abstract

Erythrocyte protoporphyrin was measured in calves by the free erythrocyte porphyrin (FEP) test. The FEP of 15 healthy calves was 142.8 +/- 32.4 micrograms/dl (mean +/- SD) of packed erythrocytes or 45.6 +/- 10.3 micrograms/dl of whole blood. Biweekly oral lead administration to 3 calves produced a continuous increase of FEP to between 2,800 and 6,033 micrograms/dl of packed erythrocytes after 20 weeks. Fluorescence scans of diluted blood were used to demonstrate that erythrocyte protoporphyrin from lead-poisoned calves was present as an approximately 2:1 mixture of zinc protoporphyrin and free protoporphyrin. Blood lead concentration increased in calves after lead was given (orally), but had greater weekly fluctuations than FEP. Mild anemia developed in 2 of 3 animals late in the experiment. Basophilic stippling of erythrocytes occurred in 1 calf.

Cite this paper

@article{George1981ErythrocytePI, title={Erythrocyte protoporphyrin in experimental chronic lead poisoning in calves.}, author={Jeanne W. George and J. Robert Duncan}, journal={American journal of veterinary research}, year={1981}, volume={42 9}, pages={1630-7} }