Erythrocyte programmed cell death

@article{Fller2008ErythrocytePC,
  title={Erythrocyte programmed cell death},
  author={Michael F{\"o}ller and Stephan M Huber and Florian Lang},
  journal={IUBMB Life},
  year={2008},
  volume={60}
}
Eryptosis, the suicidal death of erythrocytes, is characterised by cell shrinkage, membrane blebbing and cell membrane phospholipid scrambling with phosphatidylserine exposure at the cell surface. Phosphatidylserine‐exposing erythrocytes are recognised by macrophages, which engulf and degrade the affected cells. Reported triggers of eryptosis include osmotic shock, oxidative stress, energy depletion, ceramide, prostaglandin E2, platelet activating factor, hemolysin, listeriolysin, paclitaxel… Expand
Methods Employed in Cytofluorometric Assessment of Eryptosis, the Suicidal Erythrocyte Death
TLDR
The present synopsis describes the experimental procedures required for the analysis of phosphatidylserine exposure at the cell surface with annexin-V, cell volume with forward scatter, cytosolic Ca2+ activity ([Ca2+]i) with Fluo3, oxidative stress with 2′,7′-dichlorodihydrofuorescein diacetate (DCFDA), and ceramide abundance with specific antibodies. Expand
Eryptosis (quasi-apoptosis) the human red blood cells. Its role in medicinal therapy
TLDR
Modern representations about eryptosis expand the authors' knowledge about the programmed death of blood cells and is more directed to create new therapeutic schemes of treatment of patients. Expand
Eryptosis, a Window to Systemic Disease
TLDR
The case is made that analysis of enhanced eryptosis may direct to the pathophysiology of systemic disease, including drug side effects, sepsis, haemolytic uremic syndrome, Wilson´s disease, phosphate depletion and a rare condition caused by a mutation in GLUT1 turning the carrier into a cation channel. Expand
Induction of Suicidal Erythrocyte Death by Novobiocin
TLDR
Whether novobiocin elicits eryptosis is explored, an effect at least in part due to entry of extracellular Ca2+ and formation of ceramide is found and removal ofextracellularCa2+ virtually abrogated the increase of annexin-V-binding following novobocin exposure. Expand
Eryptosis: An Erythrocyte's Suicidal Type of Cell Death
TLDR
Eryptosis ensures healthy erythrocyte quantity in circulation whereas excessive eryptosis may set an environment for the clinical presence of pathophysiological conditions including anaemia. Expand
Enhanced Apoptotic Death of Erythrocytes Induced by the Mycotoxin Ochratoxin A
TLDR
Ochratoxin A triggers suicidal erythrocyte death or eryptosis, an effect partially but not fully due to stimulation of Ca2+-entry, which may lead to anemia. Expand
Silver ion‐induced suicidal erythrocyte death
TLDR
The present study explored the effect of AgNO3 on eryptosis, the suicidal death of erythrocytes, cells devoid of mitochondria, and found an effect attributed to ATP depletion, PKC activation and decrease of cellular NO. Expand
Induction of apoptotic erythrocyte death by rotenone.
TLDR
The present observations disclose a novel effect of rotenone, i.e. triggering of erythrocyte shrinkage and cell membrane scrambling, an effect paralleled by and partially dependent on Ca(2+)-entry. Expand
Ion Transport in Eryptosis, the Suicidal Death of Erythrocytes
  • M. Föller, F. Lang
  • Medicine, Chemistry
  • Frontiers in Cell and Developmental Biology
  • 2020
TLDR
The significance and mechanisms of eryptosis as well as on the ion fluxes involved are focused on, while a short summary of further ion transport mechanisms of the erythrocyte membrane is provided. Expand
Effect of Dermaseptin on Erythrocytes
TLDR
This study explored whether dermaseptin modifies [Ca2+]i and elicits eryptosis, an effect at least partially due to entry of extracellular Ca2+. Expand
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