Erythrocyte membrane topo-optical staining reflects glycoprotein conformational changes.

The study is concerned with the relationship of induced birefringence to conformational alterations of glycocalyx glycoproteins. Human erythrocytes washed with phosphate-buffered saline (PBS) and fixed with glutaraldehyde exhibit the most intense topo-optical staining, which is thought to reflect the lipid bound state of glycophorins. Incubations at reduced… CONTINUE READING