Erythrocyte membrane fluidity in malignant hyperthermia.

@article{Cooper1991ErythrocyteMF,
  title={Erythrocyte membrane fluidity in malignant hyperthermia.},
  author={P Cooper and Jonathan B. Meddings},
  journal={Biochimica et biophysica acta},
  year={1991},
  volume={1069 2},
  pages={
          151-6
        }
}
Malignant hyperthermia (MH) is a rare but serious complication of general anesthesia that potentially carries a high mortality and morbidity. It is associated with excessive release of calcium into skeletal muscle following exposure to certain drugs, including the volatile general anesthetics. Since these are recognized membrane fluidizing agents it has been speculated that this condition might represent a generalized defect in membrane physical properties either at rest or inducible by… Expand
Chapter 29 – Malignant Hyperthermia
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References

SHOWING 1-10 OF 11 REFERENCES
Abnormal fluidity state in membranes of malignant hyperthermia pig skeletal muscle.
TLDR
It is suggested that an overall increase in membrane fluidity may be implied in the MH disease, improving the general membrane defect hypothesis for this syndrome. Expand
Temperature-dependent abnormalities of the erythrocyte membrane in porcine malignant hyperthermia.
TLDR
There may be a generalized membrane defect in MH pigs which is reflected in the red blood cell as an altered membrane composition or organization according to altered temperature dependence of Mg-ATPase activity and spin probe motion in membranes derived from MH red blood cells. Expand
Erythrocyte Fragility Screening Is Not a Tool for Diagnosis of Human Malignant Hyperthermia
TLDR
Despite examining six different incubating conditions and the two methods of hemolysis induction, no differences in erythrocyte fragility were detected between patients diagnosed as MH susceptible or normal. Expand
Effects of anaesthetic agents on erythrocyte fragility: comparison of normal and malignant hyperthermia susceptible patients
TLDR
Although sampling a larger patient population might reveal slight differences between the groups, erythrocyte fragility tests do not appear to be useful in differentiating malignant hyperthermia susceptible from normal patients. Expand
An electron paramagnetic resonance study of skeletal muscle membrane fluidity in malignant hyperthermia.
TLDR
There is no evidence for a generalized membrane defect affecting lipid mobility in these MHS muscle membranes, and the rotational dynamics of lipid hydrocarbon chain motion was examined by electron paramagnetic resonance (EPR) spectroscopy. Expand
Detection of malignant hyperthermia susceptibility using a spin label technique on red blood cells.
TLDR
It is observed that halothane 3 mmol litre-1 produced a much greater decrease in the rotational correlation time of red blood cells from individuals who were at risk for malignant hyperthermia, compared with normals. Expand
Lipid structural order parameters (reciprocal of fluidity) in biomembranes derived from steady-state fluorescence polarization measurements.
Abstract This paper presents an interpretation of fluorescence polarization measurements in lipid membranes which are labelled with the apolar probe 1,6-diphenyl-1,3,5-hexatriene. The steady-stateExpand
The removal of leukocytes and platelets from whole blood.
TLDR
This procedure is rapid, reliable, removes over 99.75 per cent of the leukocytes from blood, and does not seem selectively to retain reticulocytes or to release a significant proportion of leukocyte enzymes. Expand
Erythrocyte osmotic fragility in hyperthermia-susceptible swine.
TLDR
It is reported that hyperthermia-susceptible swine manifest an increased red cell osmotic fragility. Expand
Clinical presentation of malignant hyperthermia.
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