Erythrocyte membrane deformability and stability: two distinct membrane properties that are independently regulated by skeletal protein associations

@article{Chasis1986ErythrocyteMD,
  title={Erythrocyte membrane deformability and stability: two distinct membrane properties that are independently regulated by skeletal protein associations},
  author={Joel Anne Chasis and Narla Mohandas},
  journal={The Journal of Cell Biology},
  year={1986},
  volume={103},
  pages={343 - 350}
}
Skeletal proteins play an important role in determining erythrocyte membrane biophysical properties. To study whether membrane deformability and stability are regulated by the same or different skeletal protein interactions, we measured these two properties, by means of ektacytometry, in biochemically perturbed normal membranes and in membranes from individuals with known erythrocyte abnormalities. Treatment with 2,3-diphosphoglycerate resulted in membranes with decreased deformability and… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 91 CITATIONS, ESTIMATED 60% COVERAGE

Stabilization of F-actin by tropomyosin isoforms regulates the morphology and mechanical behavior of red blood cells

  • Molecular biology of the cell
  • 2017
VIEW 6 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1987
2019

CITATION STATISTICS

  • 3 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 27 REFERENCES

Identification of functional domains of human erythrocyte spectrin.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1980
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL

Cleavage of structural proteins during

VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL

Modulation of RBC membrane mechanical fragility by 2,3-DPG in transient neonatal poikilocytosis

W. C. Mentzer, T. A. larocci, N. Mohandas
  • Blood. 64(Suppl. 1):28n
  • 1984
VIEW 3 EXCERPTS