Erythrocyte-mediated delivery of pravastatin: in vitro study of effect of hypotonic lysis on biochemical parameters and loading efficiency.

Abstract

Exposure of erythrocytes to hypotonic lysis creates pores in the cell membrane, through which pravastatin can enter and become trapped, after resealing them with a suitable buffer. We investigated the effects of tonicity, incubation time and drug concentration on drug loading into erythrocytes. Furthermore, we investigate the effects of pravastatin on… (More)
DOI: 10.1007/s12272-012-0813-4

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@article{Harisa2012ErythrocytemediatedDO, title={Erythrocyte-mediated delivery of pravastatin: in vitro study of effect of hypotonic lysis on biochemical parameters and loading efficiency.}, author={Gamaleldin Ibrahim Harisa and Mohamed F. Ibrahim and Fars Kaed Alanazi}, journal={Archives of pharmacal research}, year={2012}, volume={35 8}, pages={1431-9} }