Erythrocyte invasion and merozoite ligand gene expression in severe and mild Plasmodium falciparum malaria.

@article{GomezEscobar2010ErythrocyteIA,
  title={Erythrocyte invasion and merozoite ligand gene expression in severe and mild Plasmodium falciparum malaria.},
  author={Natalia Gomez-Escobar and Alfred Amambua-Ngwa and Michael J Walther and Joseph Okebe and Augustine O. Ebonyi and David J Conway},
  journal={The Journal of infectious diseases},
  year={2010},
  volume={201 3},
  pages={444-52}
}
Erythrocyte invasion is central to malaria parasite replication and virulence. Plasmodium falciparum parasites use different alternative erythrocyte receptors and vary in expression of erythrocyte-binding antigenic (EBA) proteins and reticulocyte-binding protein homologues (Rh). Parasite invasion phenotypes and schizont-stage transcript expression profiles of the 8 eba and Rh protein-coding genes without internal stop codons were determined for 163 clinical isolates cultured ex vivo in The… CONTINUE READING
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