Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease.

@article{Morris2008ErythrocyteGD,
  title={Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease.},
  author={Claudia R. Morris and Jung Hwa Suh and Ward Hagar and Sandra K. Larkin and David A Bland and Martin H Steinberg and Elliott Vichinsky and Mark K. Shigenaga and Bruce N. Ames and Frans A. Kuypers and E. S. Klings},
  journal={Blood},
  year={2008},
  volume={111 1},
  pages={402-10}
}
Erythrocyte glutathione depletion has been linked to hemolysis and oxidative stress. Glutamine plays an additional antioxidant role through preservation of intracellular nicotinamide adenine dinucleotide phosphate (NADPH) levels, required for glutathione recycling. Decreased nitric oxide (NO) bioavailability, which occurs in the setting of increased hemolysis and oxidative stress, contributes to the pathogenesis of pulmonary hypertension (PH) in sickle cell disease (SCD). We hypothesized that… CONTINUE READING