Erythrocyte density in sickle cell syndromes is associated with specific clinical manifestations and hemolysis.

@article{Bartolucci2012ErythrocyteDI,
  title={Erythrocyte density in sickle cell syndromes is associated with specific clinical manifestations and hemolysis.},
  author={Pablo Bartolucci and Carlo Brugnara and Armando Teixeira-Pinto and Serge Pissard and Kamran Moradkhani and H{\'e}l{\'e}ne Jouault and Fr{\'e}d{\'e}ric Galact{\'e}ros},
  journal={Blood},
  year={2012},
  volume={120 15},
  pages={
          3136-41
        }
}
Dense, dehydrated red blood cells (DRBCs) are a characteristic feature of sickle-cell disease (SCD). DRBCs play a role in the pathophysiology of SCD acute and chronic organ damage because of heightened tendency to undergo polymerization and sickling because of their higher hemoglobin S concentration. Relations between red cell density (assessed with phthalate density-distribution profile method) and several hematologic, biochemical, genetic parameters, and clinical manifestations were studied… 
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Genome-wide association study of erythrocyte density in sickle cell disease patients.
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