Erythrocyte ascorbate recycling: antioxidant effects in blood.

  title={Erythrocyte ascorbate recycling: antioxidant effects in blood.},
  author={Seema Mendiratta and Zhenhuan Qu and James Michael May},
  journal={Free radical biology & medicine},
  volume={24 5},
Ascorbic acid is an important antioxidant in human plasma, but requires efficient recycling from its oxidized forms to avoid irreversible loss. Human erythrocytes prevented oxidation of ascorbate in autologous plasma, an effect that required recycling of ascorbate within the cells. Erythrocytes had a high capacity to take up dehydroascorbate, the two-electron oxidized product of ascorbate, and to reduce it to ascorbate. Uptake and conversion of dehydroascorbate to ascorbate was saturable, was… CONTINUE READING


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