Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy

@article{Reddy2008ErythrocyteAR,
  title={Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy},
  author={G Bhanuprakash Reddy and Alleboena Satyanarayana and N. Balakrishna and Radha Ayyagari and Madakasira Padma and Kalluru Viswanath and J. Mark Petrash},
  journal={Molecular Vision},
  year={2008},
  volume={14},
  pages={593 - 601}
}
PURPOSE Activation of polyol pathway due to increased aldose reductase (ALR2) activity has been implicated in the development of diabetic complications including diabetic retinopathy (DR), a leading cause of blindness. However, the relationship between hyperglycemia-induced activation of polyol pathway in retina and DR is still uncertain. We investigated… CONTINUE READING