Erythrocyte adherence to endothelium in sickle-cell anemia. A possible determinant of disease severity.

@article{Hebbel1980ErythrocyteAT,
  title={Erythrocyte adherence to endothelium in sickle-cell anemia. A possible determinant of disease severity.},
  author={Robert P. Hebbel and M. A. Boogaerts and John W. Eaton and Martin H Steinberg},
  journal={The New England journal of medicine},
  year={1980},
  volume={302 18},
  pages={992-5}
}
We studied 33 patients with sickle-cell anemia to examine the possible relation between the severity of their disease (frequency of microvascular occlusions) and the abnormal adherence of sickle erythrocytes to cultured human endothelium. Neither clinical severity nor erythrocyte adherence correlates significantly with red-cell indexes, hemoglobin concentration, percentage of irreversibly sickled red cells, level of fetal hemoglobin, or reticulocyte count. However, clinical severity and… CONTINUE READING