Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C

@article{MontelHagen2008ErythrocyteGT,
  title={Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C},
  author={Am{\'e}lie Montel-Hagen and S. Kinet and N. Manel and C{\'e}dric Mongellaz and R. Prohaska and J. Battini and J. Delaunay and M. Sitbon and N. Taylor},
  journal={Cell},
  year={2008},
  volume={132},
  pages={1039-1048}
}
Of all cells, human erythrocytes express the highest level of the Glut1 glucose transporter. However, the regulation and function of Glut1 during erythropoiesis are not known. Here, we report that glucose transport actually decreases during human erythropoiesis despite a >3-log increase in Glut1 transcripts. In contrast, Glut1-mediated transport of L-dehydroascorbic acid (DHA), an oxidized form of ascorbic acid (AA), is dramatically enhanced. We identified stomatin, an integral erythrocyte… Expand
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TLDR
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