Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C

@article{MontelHagen2008ErythrocyteGT,
  title={Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C},
  author={Am{\'e}lie Montel-Hagen and Sandrina Kinet and Nicolas Manel and C{\'e}dric Mongellaz and Rainer Prohaska and Jean-Luc Battini and Jean Delaunay and Marc Sitbon and Naomi Taylor},
  journal={Cell},
  year={2008},
  volume={132},
  pages={1039-1048}
}
Of all cells, human erythrocytes express the highest level of the Glut1 glucose transporter. However, the regulation and function of Glut1 during erythropoiesis are not known. Here, we report that glucose transport actually decreases during human erythropoiesis despite a >3-log increase in Glut1 transcripts. In contrast, Glut1-mediated transport of L-dehydroascorbic acid (DHA), an oxidized form of ascorbic acid (AA), is dramatically enhanced. We identified stomatin, an integral erythrocyte… CONTINUE READING
92 Citations
60 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 92 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 60 references

C

  • P. G. Morgan, E. B. Kayser, M. M. Sedensky
  • elegans and volatile anesthetics. WormBook 1, 1…
  • 2007
2 Excerpts

Similar Papers

Loading similar papers…