Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C

  title={Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C},
  author={Am{\'e}lie Montel-Hagen and S. Kinet and N. Manel and C{\'e}dric Mongellaz and R. Prohaska and Jean-Luc Battini and J. Delaunay and M. Sitbon and N. Taylor},
  • Amélie Montel-Hagen, S. Kinet, +6 authors N. Taylor
  • Published 2008
  • Biology, Medicine
  • Cell
  • Of all cells, human erythrocytes express the highest level of the Glut1 glucose transporter. However, the regulation and function of Glut1 during erythropoiesis are not known. Here, we report that glucose transport actually decreases during human erythropoiesis despite a >3-log increase in Glut1 transcripts. In contrast, Glut1-mediated transport of L-dehydroascorbic acid (DHA), an oxidized form of ascorbic acid (AA), is dramatically enhanced. We identified stomatin, an integral erythrocyte… CONTINUE READING
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    Paper Mentions

    Pharmacokinetics is the term used for how the body affects a drug once it is taken. Vitamin C, also known as ascorbic acid, is an essential water soluble vitamin. Meaning, the body does… Expand
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    Erythroid glucose transporters
    • 51
    Human erythrocytes transport dehydroascorbic acid and sugars using the same transporter complex.
    • 25
    Response: Species Diversity in GLUT Expression and Function
    • 6
    Glut-1 explains the evolutionary advantage of the loss of endogenous vitamin C-synthesis
    Vitamin C transporters
    • 82
    The sodium-dependent ascorbic acid transporter family SLC23.
    • 47
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    • 34


    Glucose Transporter Isoforms GLUT1 and GLUT3 Transport Dehydroascorbic Acid*
    • 390
    • Highly Influential
    • PDF
    Glucose-Independent Transport of Dehydroascorbic Acid in Human Erythrocytes 1
    • J. Bianchi, R. C. Rose
    • Chemistry, Medicine
    • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
    • 1986
    • 41
    Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid
    • 458
    A family of mammalian Na+-dependent L-ascorbic acid transporters
    • 718
    Ascorbate function and metabolism in the human erythrocyte.
    • J. May
    • Medicine, Biology
    • Frontiers in bioscience : a journal and virtual library
    • 1998
    • 104
    • PDF
    Mechanisms of ascorbic acid recycling in human erythrocytes.
    • 65
    Human erythrocyte sugar transport is incompatible with available carrier models.
    • 72
    Facilitative glucose transporters.
    • M. Mueckler
    • Medicine, Biology
    • European journal of biochemistry
    • 1994
    • 1,028
    • Highly Influential
    Association of stomatin (band 7.2b) with Glut1 glucose transporter.
    • 60