Erythrocyte Aging: A More than Superficial Resemblance to Apoptosis?

  title={Erythrocyte Aging: A More than Superficial Resemblance to Apoptosis?},
  author={G. Bosman and F. L. Willekens and J. Werre},
  journal={Cellular Physiology and Biochemistry},
  pages={1 - 8}
  • G. Bosman, F. L. Willekens, J. Werre
  • Published 2005
  • Biology, Medicine
  • Cellular Physiology and Biochemistry
  • In physiological circumstances, erythrocyte aging leads to binding of autologous IgG followed by recognition and removal through phagocytosis, mainly by Kupffer cells in the liver. This process is triggered by the appearance of a senescent erythrocyte-specific antigen. The functional and structural characteristics of senescent erythrocytes strongly suggest that this antigen originates on band 3, probably by calcium-induced proteolysis. Generation of vesicles enriched in denatured hemoglobin is… CONTINUE READING
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