Erythroblasts secrete the nonclassical HLA-G molecule from primitive to definitive hematopoiesis.

  title={Erythroblasts secrete the nonclassical HLA-G molecule from primitive to definitive hematopoiesis.},
  author={Catherine Menier and Mich{\`e}le Rabreau and J. C. Challier and Magali Le Discorde and Edgardo D. Carosella and Nathalie Rouas-Freiss},
  volume={104 10},
The initial steps of primitive hematopoiesis and endothelial vascular formation in the human embryo remain to be defined. Here, we report the identification of a novel marker, namely the nonclassical HLA-G class I molecule, which targets both primitive erythroid cells of the yolk sac and endothelial cells from developing vessels. Moreover, HLA-G was present in its soluble form in the erythropoietic lineage in all organs sustaining primitive to definitive erythropoiesis (ie, aorta-gonad… CONTINUE READING


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