Erythema‐multiforme‐like eruption following photoallergic contact dermatitis from oxybenzone

  title={Erythema‐multiforme‐like eruption following photoallergic contact dermatitis from oxybenzone},
  author={Xiao-Min Zhang and Mikio Nakagawa and Keiichi Kawai and Kyozo Kawai},
  journal={Contact Dermatitis},
Many contact allergens can cause an erythema‐multifor‐me (EM)‐like or urticarial papular and plaque eruption (UPPE) (1–6). Although numerous topical medicaments have been reported as causing UPPE, oxybenzone (2‐hydroxy‐4‐methoxy benzophenone, benzophenone 3, Eusolex 4360) has not. 
Photoallergic contact dermatitis
Background: Photoallergic contact dermatitis (PACD) presents in patients after certain exogenous agents come into contact with the skin in the presence of ultraviolet and/or visible light. The best
1,2-Ethanedithiol-induced erythema multiforme-like contact dermatitis.
A 22-year-old female chemistry student who developed widespread erythema multiforme-like lesions after local contact with 1,2-ethanedithiol, which serves as a protective group in chemical synthesis, is reported on.
Facial erythema as a result of benzophenone allergy.
  • S. Nedorost
  • Medicine
    Journal of the American Academy of Dermatology
  • 2003
Photoallergic contact dermatitis
  • A. Goossens
  • Medicine, Physics
    Photodermatology, photoimmunology & photomedicine
  • 2004
Whether photoallergic contact dermatitis is as uncommon as it is usually considered to be and to review the associated clinical features is reviewed.
Rates of allergic sensitization and irritation to oxybenzone‐containing sunscreen products: a quantitative meta‐analysis of 64 exaggerated use studies
A meta‐analysis was conducted to determine the safety of oxybenzone in participants recruited from the general population, and found that the reported incidence of allergic reactions to oxyben Zone in these studies may be overestimated as related to the generalpopulation.
Sunscreen Allergy: A Review of Epidemiology, Clinical Characteristics, and Responsible Allergens
The epidemiology and clinical characteristics of sunscreen allergy are summarized in this review and a detailed discussion of specific chemical sunscreen allergens is provided.
Drug-Induced Photosensitivity: Clinical Types of Phototoxicity and Photoallergy and Pathogenetic Mechanisms
The pathogenetic mechanisms and causative drugs of drug-induced photosensitivity are reported, which include phototoxicity and photoallergy, and suggestions on how to improve sun exposure behaviors of patients at risk of DIP are made.
Adverse reactions to sunscreen agents: epidemiology, responsible irritants and allergens, clinical characteristics, and management.
This review focuses on the 36 most common UV filters in commercial and historical use, and the benzophenones and dibenzoylmethanes are the most commonly implicated UV filters causing allergic and photoallergic contact dermatitis (PACD) reactions.
True Photoallergy to Sunscreens Is Rare Despite Popular Belief
This study parallels prior studies in concluding that true delayed type IV hypersensitivity (allergic contact dermatitis and photoallergy to sunscreens is more infrequent than patients tend to believe.
A review of sunscreens and their adverse reactions.
The use of sunscreens has increased steadily over the last decade; as a result, allergy and photoallergy to UV filters are now more frequent than in the past.


Photoallergic contact dermatitis to oxybenzone
A 21‐year‐old woman developed an erythematous papulovesicular eruption of photo‐exposed sites, following the use of an oxybenzone‐containing sunscreen, which produced findings strongly suggestive of Oxybenzone photoallergy.
Erythema‐multiforme‐like, urticarial papular and plaque eruptions from bufexamac: report of 4 cases
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After suspension of the topical corticosteroid, the dermatitis quickly improved without further treatment and the girl showed a fresh outbreak oflesions and an erythema-multiformelike eruption on the hands, forearms and face.
Erythema‐multiforme‐like eruption following allergic contact dermatitis from sesquiterpene luctones in herbal medicine
Allergologische Untersuchungen beim Lyeli-Syndrom, also known as Nekrolytische ArzneiExantheme, are published here.
Erythema‐multiforme‐like eruption from antibiotics of 3 different groups
A 55-year-old woman hospitalized for post-operative necrotic pancreatitis, with fever, was treated with several antibiotics: tobramycin, clindamycin, cephalothin and cephalexin, and dermatitis and fever subsided a few days after stopping the antibiotics.
Photoallergic contact dermatitis from oxybenzone aggravating polymorphic light eruption
The patient, a 28-year-old woman, had suffered mild PLE limited to the V of her neck since 1980, but when she applied Caribe Factor 20 Babyscreen® to her face and upper chest, prior to spending several hours in the sunshine wearing a bikini top and shorts, she developed a painful eczematous eruption confined to the areas of sunscreen application.
Contact and photocontact allergy to oxybenzone *
Oxybenzone was found to cause 4 cases of allergic contact dermatitis, and 3 cases of photocontact dermatitis (13% of patients), probably due to the wide distribution of oxybenzone in sunscreens and other cosmetics.
Contact and photocontact allergy to oxybenzone and mexenone
Oxybenzone (2-hydroxy-4-methoxybenzophenone; benzophenone-3; Eusolex® 4360) is by far the most frequently used agent in sunscreens with a sun protection factor (SPF) greater than 8.
Allergic contact cheilitis from a lipstick containing oxybenzone
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