Erysothrine, an alkaloid extracted from flowers of Erythrina mulungu Mart. ex Benth: evaluating its anticonvulsant and anxiolytic potential.

@article{Rosa2012ErysothrineAA,
  title={Erysothrine, an alkaloid extracted from flowers of Erythrina mulungu Mart. ex Benth: evaluating its anticonvulsant and anxiolytic potential.},
  author={Daiane Santos Rosa and Silmara Aparecida Faggion and Amanda Salom{\~a}o Gavin and Maicon Anderson de Souza and Helene Aparecida Fachim and Wagner Ferreira dos Santos and Ana Maria Soares Pereira and Alexandra Olimpio Siqueira Cunha and Ren{\^e} de Oliveira Beleboni},
  journal={Epilepsy & behavior : E&B},
  year={2012},
  volume={23 3},
  pages={205-12}
}
In this study, we isolated the alkaloid erysothrine from the hydroalcoholic extract of flowers from E. mulungu and screened for its anticonvulsant and anxiolytic actions based on neuroethological and neurochemical experiments. Our results showed that the administration of erysothrine inhibited seizures evoked by bicuculline, PTZ, NMDA and most remarkably, kainic acid. Also, erysothrine induced an increase in the number of entries but not in the time spent in the open arms of the EPM. However… CONTINUE READING
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