Errors in erasure: links between histone lysine methylation removal and disease.

@article{Duncan2011ErrorsIE,
  title={Errors in erasure: links between histone lysine methylation removal and disease.},
  author={Elizabeth M. Duncan and C David Allis},
  journal={Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques},
  year={2011},
  volume={67},
  pages={69-90}
}
Many studies have demonstrated that covalent histone modifications are dynamically regulated to cause both chemical and physical changes to the chromatin template. Such changes in the chromatin template lead to biologically significant consequences, including differential gene expression. Histone lysine methylation, in particular, has been shown to correlate with gene expression both positively and negatively, depending on the specific site and degree (i.e., mono-, di-, or tri-) of methylation… CONTINUE READING